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Connecting Chromosomes, Crisis, and Cancer

26 Jul 2002

Abstract excerpt

Cancer is a disease of impaired genome stability. The molecular forces that maintain genome integrity and sense altered chromosome structure are invariably subverted in cancer cells. Here, we explore the contrasting contributions of telomeres in the initiation and suppression of cancer and review the evidence supporting a role for telomere dysfunction as a mechanism driving the radical chromosomal aberrations...

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Identifiers

PMID: 12142527
DOI: 10.1126/science.297.5581.565

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