Back to search

Article

NK cell-induced damage to <i>P.falciparum</i> -infected erythrocytes requires ligand-specific recognition and releases parasitophorous vacuoles that are phagocytosed by monocytes in the presence of immune IgG

2023-08-02

Abstract excerpt

Natural killer (NK) cells lyse virus-infected cells and transformed cells through polarized delivery of lytic effector molecules into target cells. We have shown that NK cells lyse Plasmodium falciparum -infected red blood cells (iRBC) via antibody-dependent cellular cytotoxicity (ADCC). A high frequency of adaptive NK cells, with elevated intrinsic ADCC activity, in people chronically exposed to malaria transmis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
26e86771-5865-5acc-bf6d-36eed33335c9
DOI
10.1101/2023.07.31.551226
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
NK cell-induced damage to <i>P.falciparum</i> -infected erythrocytes requires ligand-specific recognition and releases parasitophorous vacuoles that are phagocytosed by monocytes in the presence of immune IgGDOI 10.1101/2023.07.31.551226
Adaptive NK cells in people exposed to Plasmodium falciparum correlate with protection from malariaSemantic proximity
Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccinationSemantic proximity
Cytolytic memory CD4 <sup>+</sup> T cell clonotypes are expanded during <i>Plasmodium falciparum</i> infectionSemantic proximity
Hepatic γδ NKT cells modulate liver-resident CD8+ T cells to attenuated malaria parasite vaccinesSemantic proximity
The role of natural killer cells in adaptive immune responsesSemantic proximity
Mechanisms underlying the monocyte-mediated antibody-dependent killing of <i>Plasmodium falciparum</i> asexual blood stagesSemantic proximity
Erythrocyte CD55 facilitates the internalization of <i>Plasmodium falciparum</i> parasitesSemantic proximity
Optimisation and validation of a new method for antibody dependent cellular phagocytosis in hepatitis C virus infection.Semantic proximity
Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes.Semantic proximity
Mechanisms of Adherence, Cytotoxicity and Phagocytosis Modulate the Pathogenesis of <i>Entamoeba Histolytica</i>Semantic proximity
Hemolysis-associated phosphatidylserine exposure promotes polyclonal plasmablast differentiationSemantic proximity
Reversible host cell surface remodelling limits immune recognition and maximizes transmission of <i>Plasmodium falciparum</i> gametocytesSemantic proximity
Select a neighboring publication to make it the new centre.