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Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination

5 Oct 2021

Abstract excerpt

Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family members mediate receptor- and tissue-specific sequestration of infected erythrocytes (IEs) in malaria. Antibody responses are a central component of naturally acquired malaria immunity. PfEMP1-specific IgG likely protects by inhibiting IE sequestration and through IgG-Fc Receptor (FcγR) mediated phagocytosis and killing of antibody-opsonized...

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PMID: 34611164
DOI: 10.1038/s41467-021-26118-w

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