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Article

Optimisation and validation of a new method for antibody dependent cellular phagocytosis in hepatitis C virus infection.

Journal of immunological methods - 1 Aug 2021

Adhikari Anurag, Eltahla Auda, Lloyd Andrew R, Rodrigo Chaturaka, Agapiou David, Bull Rowena A, Tedla Nicodemus

Abstract excerpt

Lack of a simple, high throughput antibody-dependent cellular phagocytosis (ADCP) assay has limited our understanding of its potential role of in hepatitis C (HCV) infection. Here, we optimised a flow-cytometry based ADCP assay using HCV envelope (E2)-protein coated microbeads that were opsonised with anti-E2 monoclonal IgG antibody (αE2 mAb) and the THP-1 monocyte cell line as effector cells. We found...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34147479
DOI: 10.1016/j.jim.2021.113087

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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