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Article

Adaptive NK cells in people exposed to Plasmodium falciparum correlate with protection from malaria

12 Apr 2019

Abstract excerpt

How antibodies naturally acquired during Plasmodium falciparum infection provide clinical immunity to blood-stage malaria is unclear. We studied the function of natural killer (NK) cells in people living in a malaria-endemic region of Mali. Multi-parameter flow cytometry revealed a high proportion of adaptive NK cells, which are defined by the loss of transcription factor PLZF and Fc receptor γ-chain. Adaptive NK...

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PMID: 30979790
DOI: 10.1084/jem.20181681

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