Back to search

Article

Spatiotemporal Mapping of Tertiary Lymphoid Structure Heterogeneity Shapes Immune Niches and Clinical Outcomes in Intrahepatic Cholangiocarcinoma

2026-01-06

Abstract excerpt

Intrahepatic cholangiocarcinoma (iCCA) is a highly lethal malignancy with limited therapeutic options. The spatial architecture and functional diversity of tertiary lymphoid structures (TLSs) in iCCA remain unclear. Here, we present a multimodal spatial atlas of TLSs and identified Intra-tumoral TLSs (iTLSs) as independent prognostic markers. Bulk proteomic profiling of 214 discovery and 155 validation cases ident...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4481526c-44ae-5917-9921-fde3cb394d9f
DOI
10.64898/2026.01.02.697439
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Spatiotemporal Mapping of Tertiary Lymphoid Structure Heterogeneity Shapes Immune Niches and Clinical Outcomes in Intrahepatic CholangiocarcinomaDOI 10.64898/2026.01.02.697439
Spatial single-cell proteomics landscape decodes the tumor microenvironmental ecosystem of intrahepatic cholangiocarcinomaSemantic proximity
Geospatial Immune Heterogeneity Reflects the Diverse Tumor-Immune Interactions in Intrahepatic Cholangiocarcinoma.Semantic proximity
Spatial and Single-Cell Transcriptomics Decipher the Crosstalk Environment of <i>DEFB1</i> <sup>+</sup> Cancer Cells and <i>IFI30</i> <sup>+</sup> Macrophages in Intrahepatic CholangiocarcinomaSemantic proximity
Single‐Cell and Spatial Transcriptomics Delineate the Microstructure and Immune Landscape of Intrahepatic Cholangiocarcinoma in the Leading‐Edge AreaSemantic proximity
Cell type-centric interaction networks define spatial architecture of intrahepatic cholangiocarcinomaSemantic proximity
Spatial resolved transcriptomics reveals distinct cross-talk between cancer cells and tumor-associated macrophages in intrahepatic cholangiocarcinomaSemantic proximity
An integrated single-cell atlas of checkpoint inhibitor-induced liver injury links shared liver-tumour CD8+ T cell clones to cytotoxicity and macrophage crosstalksSemantic proximity
Single-cell landscape of immunocytes in patients with extrahepatic cholangiocarcinomaSemantic proximity
Spatial multi-omics reveal intratumoral humoral immunity niches associated with tertiary lymphoid structures in pancreatic cancer immunotherapy pathologic respondersSemantic proximity
Deep immune profiling of intrahepatic cholangiocarcinoma with CODEX multiplexed imagingSemantic proximity
Mapping of the T-cell Landscape of Biliary Tract Cancer Unravels Anatomic Subtype-Specific HeterogeneitySemantic proximity
Single-Cell Transcriptomic Analysis Reveals Two Molecularly and Clinically Distinct Subtypes of Intrahepatic CholangiocarcinomaSemantic proximity
Select a neighboring publication to make it the new centre.