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Article

Mitochondrial dysfunction and metabolic reprogramming induce macrophage pro-inflammatory phenotype switch and atherosclerosis progression in aging.

Frontiers in immunology - 1 Jan 2024

Vendrov Aleksandr E, Lozhkin Andrey, Hayami Takayuki, Levin Julia, Silveira Fernandes Chamon Jamille, Abdel-Latif Ahmed, Runge Marschall S, Madamanchi Nageswara R

Abstract excerpt

Introduction: Aging increases the risk of atherosclerotic vascular disease and its complications. Macrophages are pivotal in the pathogenesis of vascular aging, driving inflammation and atherosclerosis progression. NOX4 (NADPH oxidase 4) expression increases with age, correlating with mitochondrial dysfunction, inflammation, and atherosclerosis. We hypothesized that the NOX4-dependent mitochondrial oxidative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38975335
DOI: 10.3389/fimmu.2024.1410832
PMCID: PMC11224442

Genes

NOX4
CD38
EGR2
CD163
CD80
CD68
IL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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