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Article

NOX isoforms in the development of abdominal aortic aneurysm.

Redox biology - 1 Apr 2017

Siu Kin Lung, Li Qiang, Zhang Yixuan, Guo Jun, Youn Ji Youn, Du Jie, Cai Hua

Abstract excerpt

Oxidative stress plays an important role in the formation of abdominal aortic aneurysm (AAA), and we have recently established a causal role of uncoupled eNOS in this severe human disease. We have also shown that activation of NADPH oxidase (NOX) lies upstream of uncoupled eNOS. Therefore, identification of the specific NOX isoforms that are required for eNOS uncoupling and AAA formation would ultimately lead to...

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Share to Angiotensin II
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27912196
DOI: 10.1016/j.redox.2016.11.002
PMCID: PMC5133668

Genes

NOX4
NOX1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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