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Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway✰

19 Oct 2019

Abstract excerpt

BACKGROUND: Aortic dissection is a severe inflammatory vascular disease with high mortality and limited therapeutic options. The hallmarks of aortic dissection comprise aortic inflammatory cell infiltration and elastic fiber disruption, highlighting the involvement of macrophage. Here a role for macrophage hypoxia-inducible factor 1-alpha (HIF-1α) in aortic dissection was uncovered. METHODS: Immunochemistry,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31640947
DOI: 10.1016/j.ebiom.2019.09.041

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