Article

Simulation-guided sloppy DNA probe design for mismatch tolerant hybridization

2022-12-21

Abstract excerpt

The ability to both sensitively and specifically assess the sequence composition of a nucleic acid strand is an ever-growing field. Designing a detection scheme that can perform this function when the sequence of the target being detected deviates significantly from the canonical sequence however is difficult in part because probe/primer design is based on established Watson-Crick base-pairing rules. We present he...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 26daf9b7-bf4c-5252-823b-114d4c1265a7
DOI: 10.1101/2022.12.20.521289

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Simulation-guided sloppy DNA probe design for mismatch tolerant hybridizationDOI 10.1101/2022.12.20.521289Read

Simulation-guided tunable DNA probe design for mismatch tolerant hybridization.Semantic proximity Read

Simulation-Guided Rational Design of DNA Probe for Accurate Discrimination of Single-Nucleotide Variants Based on "Hill-Type" Cooperativity.Semantic proximity Read

Tuning the specificity of DNA probes using bulge-loops for low-abundance SNV detection.Semantic proximity Read

Plug-and-Play Competitive Hairpin Conversion Module Enables Enzyme-Free High-Resolution Discrimination of Single Nucleotide Polymorphisms.Semantic proximity Read

Expanding detection windows for discriminating single nucleotide variants using rationally designed DNA equalizer probes.Semantic proximity Read

An Engineered Kinetic Amplification Mechanism for Single Nucleotide Variant Discrimination by DNA Hybridization Probes.Semantic proximity Read

A kinetically controlled, isothermal method for the detection of single nucleotide mismatches.Semantic proximity Read

Exquisite allele discrimination by toehold hairpin primers.Semantic proximity Read

Exquisite sequence selectivity with small conditional RNAs.Semantic proximity Read

Mutation signature filtering enables high-fidelity RNA structure probing at all four nucleobases with DMS.Semantic proximity Read

Massively parallel single molecule tracking of sequence-dependent DNA mismatch repair <i>in vivo</i>Semantic proximity Read

Heteromultivalency enables enhanced detection of nucleic acid mutations.Semantic proximity Read