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Article

Exquisite allele discrimination by toehold hairpin primers.

Nucleic acids research - 1 Sept 2014

Byrom Michelle, Bhadra Sanchita, Jiang Yu Sherry, Ellington Andrew D

Abstract excerpt

The ability to detect and monitor single nucleotide polymorphisms (SNPs) in biological samples is an enabling research and clinical tool. We have developed a surprising, inexpensive primer design method that provides exquisite discrimination between SNPs. The field of DNA computation is largely reliant on using so-called toeholds to initiate strand displacement reactions, leading to the execution of kinetically...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24990378
DOI: 10.1093/nar/gku558
PMCID: PMC4150758

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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