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Article

A kinetically controlled, isothermal method for the detection of single nucleotide mismatches.

Bioorganic & medicinal chemistry letters - 1 Sept 2018

Masaki Yoshiaki, Cayer Devon, McBride Ryan, Ghadiri M Reza

Abstract excerpt

We describe an isothermal, enzyme-free method to detect single nucleotide differences between oligonucleotides of close homology. The approach exploits kinetic differences in toe-hold-mediated, nucleic acid strand-displacement reactions to detect single nucleotide polymorphisms (SNPs) with essentially "digital" precision. The theoretical underpinning, experimental analyses, predictability, and accuracy of this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29500066
DOI: 10.1016/j.bmcl.2018.02.024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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