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Article

Expanding detection windows for discriminating single nucleotide variants using rationally designed DNA equalizer probes.

Nature communications - 29 Oct 2020

Wang Guan A, Xie Xiaoyu, Mansour Hayam, Chen Fangfang, Matamoros Gabriela, Sanchez Ana L, Fan Chunhai, Li Feng

Abstract excerpt

Combining experimental and simulation strategies to facilitate the design and operation of nucleic acid hybridization probes are highly important to both fundamental DNA nanotechnology and diverse biological/biomedical applications. Herein, we introduce a DNA equalizer gate (DEG) approach, a class of simulation-guided nucleic acid hybridization probes that drastically expand detection windows for discriminating...

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Identifiers

PMID: 33122648
DOI: 10.1038/s41467-020-19269-9
PMCID: PMC7596233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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