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Article

4R tau drives endolysosomal and autophagy dysfunction in frontotemporal dementia.

Autophagy - 1 May 2024

Hung Christy, Patani Rickie

Abstract excerpt

Dysfunction of the neuronal endolysosome and macroautophagy/autophagy pathway is emerging as an important pathogenic mechanism in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The VCP (valosin-containing protein) gene is of significant relevance, directly implicated in both FTD and ALS. In our recent study, we used patient-derived stem cells to study the effects of VCP mutations on the...

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Identifiers

PMID: 38174587
DOI: 10.1080/15548627.2023.2300917
PMCID: PMC11135858

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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