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Tau differentially regulates the transport of early endosomes and lysosomes

21 Sept 2022

Abstract excerpt

Microtubule-associated proteins (MAPs) modulate the motility of kinesin and dynein along microtubules to control the transport of vesicles and organelles. The neuronal MAP tau inhibits kinesin-dependent transport. Phosphorylation of tau at Tyr-18 by fyn kinase results in weakened inhibition of kinesin-1. We examined the motility of early endosomes and lysosomes in cells expressing wild-type (WT) tau and...

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PMID: 36129768
DOI: 10.1091/mbc.e22-01-0018

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