Article

SOX11 stimulates γδ T-cell differentiation and synergizes with LMO2 and MYCN to drive γδ-like T-cell acute lymphoblastic leukemia

2026-07-29

Abstract excerpt

T-cell acute lymphoblastic leukemia (T-ALL) is a heterogeneous hematologic malignancy in which LMO2 γδ-like T-ALL represents a rare but clinically aggressive subtype associated with poor treatment response and inferior survival. Integrated transcriptomic analyses identified high SOX11 expression as a defining feature of high-risk LMO2 γδ-like T-ALL, where elevated SOX11 levels correlated with refractory disease an...

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Literature Corpus work: 26abac03-aaf1-5a84-a696-4532edbd457b
DOI: 10.64898/2026.07.28.741231

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