Article
Homeodomain-driven oncogenic diversion to a γδTCR phenotype in T-cell acute lymphoblastic leukemia.
Blood - 4 Jun 2026
Pinton Antoine, Courtois Lucien, Delafoy Manon, Bonnet Mickaël, Cieslak Agata, Lhermitte Ludovic, Simonin Mathieu, Dourthe Marie-Emilie, Touzart Aurore, Andrieu Guillaume P, Dombret Hervé, Baruchel André, Spicuglia Salvatore, Payet-Bornet Dominique, Boissel Nicolas, Macintyre Elizabeth, Asnafi Vahid
Abstract excerpt
ABSTRACT: T-cell acute lymphoblastic leukemia (T-ALL) results from the malignant transformation of thymocytes blocked in their differentiation. Surface expression of the γδ T-cell receptor (γδTCR) is surprisingly frequent in T-ALLs, questioning the susceptibility of the γδ-lineage to leukemogenesis. Among 1233 T-ALLs phenotyped in our center, 33% (n = 403) expressed a TCR, of which 47% (n = 191; 113 adults, 78...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.