Article

Targeting LMO2-induced autocrine FLT3 signalling to overcome chemoresistance in early T-cell precursor acute lymphoblastic leukemia

2024-08-16

Abstract excerpt

<title>Abstract</title> <p>Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) is characterised by aberrant expression of the LMO2-LYL1 stem-cell transcription factor complex, activating mutations of cytokine receptor signalling and poor response to intensive chemotherapy. Previously, studies of the Lmo2 transgenic mouse model of ETP-ALL identified a population of stem-like T-cell progenitors with long-...

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Literature Corpus work: 085e3373-0c2a-55f1-bede-e9f1ccc3f6c1
DOI: 10.21203/rs.3.rs-4608404/v1

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