Article

CDKN1A is a target for phagocytosis-mediated cellular immunotherapy in acute leukemia

2022-01-20

Abstract excerpt

<h4>Summary</h4> Most tumor-associated macrophages (TAMs), which are abundant in the tumor microenvironment, demonstrate an immunosuppressive phenotype and contribute to tumor progression, treatment resistance and poor clinical outcomes 1,2 . Due to their functional plasticity, these cells could be reprogrammed to acquire a pro-inflammatory phenotype and promote tumor clearance 1 . Several therapeutic approache...

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Literature Corpus work: 26aa34f2-1d2b-5105-993f-998fa8aba11d
DOI: 10.1101/2022.01.18.476736

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