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Article

TIGIT blockade repolarizes AML-associated TIGIT+ M2 macrophages to an M1 phenotype and increases CD47-mediated phagocytosis.

Journal for immunotherapy of cancer - 1 Dec 2022

Brauneck Franziska, Fischer Brit, Witt Marius, Muschhammer Jana, Oelrich Jennyfer, da Costa Avelar Pedro Henrique, Tsoka Sophia, Bullinger Lars, Seubert Elisa, Smit Daniel J, Bokemeyer Carsten, Ackermann Christin, Wellbrock Jasmin, Haag Friedrich, Fiedler Walter

Abstract excerpt

BACKGROUND: Leukemia-associated macrophages (LAMs) represent an important cell population within the tumor microenvironment, but little is known about the phenotype, function, and plasticity of these cells. The present study provides an extensive characterization of macrophages in patients with acute myeloid leukemia (AML). METHODS: The phenotype and expression of coregulatory markers were assessed on bone marrow...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36549780
DOI: 10.1136/jitc-2022-004794
PMCID: PMC9791419

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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