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Article

Variable ectopic heterochromatin islands provide an alternative route to antifungal heteroresistance in <i>Cryptococcus neoformans</i>

2026-06-11

Abstract excerpt

The fungal pathogen Cryptococcus neoformans is estimated to cause approximately 180,000 deaths annually, primarily among immunocompromised HIV patients in resource-limited countries in central and southern Africa. Economic constraints regularly restrict treatment to fluconazole monotherapy. Unstably resistant cells arise in any otherwise fluconazole-sensitive C. neoformans population, with such ‘heteroresistance...

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Literature Corpus work
26a71f44-5826-5f38-b81d-08291d58322a
DOI
10.64898/2026.06.10.731255
Open publication

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Variable ectopic heterochromatin islands provide an alternative route to antifungal heteroresistance in <i>Cryptococcus neoformans</i>DOI 10.64898/2026.06.10.731255
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