Article

Natural mismatch repair mutations mediate phenotypic diversity and drug resistance in <i>Cryptococcus deuterogattii</i>

2017-05-24

Abstract excerpt

Pathogenic microbes confront a constant evolutionary conflict between the pressure to maintain genome stability and the need to adapt to mounting external stresses. Prokaryotes often respond with elevated mutation rates, but to date little evidence exists of stable eukaryotic hypermutators in nature. Whole genome resequencing of the human fungal pathogen Cryptococcus deuterogattii identified an outbreak lineage c...

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Literature Corpus work: 718581e1-ab43-58b5-91cb-fd65fb40e1c6
DOI: 10.1101/141507

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