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Article

Epimutations driven by RNAi or heterochromatin evoke transient antimicrobial drug resistance in pathogenic Mucor fungi.

PLoS biology - 1 Feb 2026

Son Ye-Eun, Pérez-Arques Carlos, Heitman Joseph

Abstract excerpt

Antimicrobial resistance (AMR) is a global health threat emerging through microbe adaptation, driven by genetic variation, genome plasticity or epigenetic processes. In this study, we investigated how the Mucor circinelloides species complex adapts to the antifungal natural product FK506, which binds to FKBP12 and inhibits calcineurin-dependent hyphal growth. In Mucor bainieri, most FK506-resistant isolates (90%)...

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Share to Antifungal Agents
Share to Drug Resistance, Fungal
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Fungal

Share to Heterochromatin

Share to RNA Interference

Share to RNA, Small Interfering

Share to Tacrolimus

Source

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Identifiers

PMID: 41628159
DOI: 10.1371/journal.pbio.3003598
PMCID: PMC12863538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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