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Article

Dynamic ploidy changes drive fluconazole resistance in human cryptococcal meningitis

27 Jan 2019

Abstract excerpt

BACKGROUND: Cryptococcal meningitis (CM) causes an estimated 180,000 deaths annually, predominantly in sub-Saharan Africa, where most patients receive fluconazole (FLC) monotherapy. While relapse after FLC monotherapy with resistant strains is frequently observed, the mechanisms and impact of emergence of FLC resistance in human CM are poorly understood. Heteroresistance (HetR) - a resistant subpopulation within...

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PMID: 30688656
DOI: 10.1172/jci124516

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