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Article

Two-step voltage-sensor activation of the human KV7.4 channel and effect of a deafness-associated mutation.

Nature communications - 5 Feb 2026

Nappi Mario, Frampton Damon J A, Kusay Ali S, Wang Kaiqian, Yasarbas S Suheda, Pozzi Serena, Miceli Francesco, Liin Sara I, Taglialatela Maurizio, Pantazis Antonios

Abstract excerpt

KCNQ4-encoded KV7.4 voltage-gated potassium channels are expressed in hair-cells of the inner ear. Loss-of-function variants in KCNQ4 cause non-syndromic progressive hearing loss (DFNA2). KV7.4 pore opening requires voltage-dependent conformational changes (activation) of the voltage-sensor domains (VSDs); however, how fast charge displacement during VSD activation is coupled to slow channel opening is currently...

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Identifiers

PMID: 41639121
DOI: 10.1038/s41467-026-69249-8
PMCID: PMC12982505

Genes

KCNQ4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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