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Article

Gating currents from Kv7 channels carrying neuronal hyperexcitability mutations in the voltage-sensing domain.

Biophysical journal - 21 Mar 2012

Miceli Francesco, Vargas Ernesto, Bezanilla Francisco, Taglialatela Maurizio

Abstract excerpt

Changes in voltage-dependent gating represent a common pathogenetic mechanism for genetically inherited channelopathies, such as benign familial neonatal seizures or peripheral nerve hyperexcitability caused by mutations in neuronal K(v)7.2 channels. Mutation-induced changes in channel voltage dependence are most often inferred from macroscopic current measurements, a technique unable to provide a detailed...

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Identifiers

PMID: 22455920
DOI: 10.1016/j.bpj.2012.02.004
PMCID: PMC3309409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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