Article

Hypergraph geometry localizes mutation-associated dependency vulnerabilities in cancer

2026-07-29

Abstract excerpt

<h4>ABSTRACT</h4> Mutation-specific therapeutic vulnerabilities remain difficult to identify in precision oncology because lineage effects and network topology can obscure true synthetic lethal relationships. Here, we present a computational framework that maps genomic mutational profiles and genome-wide CRISPR-Cas9 screens onto multi-scale hypergraphs constructed from macromolecular complexes (CORUM), protein in...

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Literature Corpus work: 268368d8-87d4-5066-94ab-1ba8691b5ba5
DOI: 10.64898/2026.07.26.740812

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