Article

A novel plasma membrane bicarbonate transporter critical for <i>Leishmania</i> virulence

2025-07-16

Abstract excerpt

Leishmania parasites survive and proliferate within the acidic phagolysosomes of host macrophages while maintaining a near-neutral cytosolic pH, a process essential for intracellular survival and virulence. Although our prior work implicated a bicarbonate-based buffering mechanism, the absence of any annotated bicarbonate transporter in the parasite genome has hindered its identification. Using an isotope ratio ma...

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Literature Corpus work: 196554b2-8d1a-5abb-a509-4f211188e7d9
DOI: 10.1101/2025.07.16.665125

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