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BACE Inhibitor Treatment in Mice Induces Hyperactivity in a Seizure-Related Gene 6 Family Protein Dependent Manner but Does Not alter Spatial Learning and Reference Memory

2021-04-13

Abstract excerpt

<h4>Background: </h4> BACE inhibitors, which decrease BACE1 (β-secretase 1) cleavage of the amyloid precursor protein, are a potential treatment for Alzheimer’s disease. Clinical trials using BACE inhibitors have reported a lack of positive effect on patient symptoms and, in some cases, have led to increased adverse events, cognitive worsening and hippocampal atrophy. A potential drawback of this strategy is the e...

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Literature Corpus work: 26791f17-b06a-5a5d-9563-ffda82ebc82c
DOI: 10.21203/rs.3.rs-396650/v1

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BACE Inhibitor Treatment in Mice Induces Hyperactivity in a Seizure-Related Gene 6 Family Protein Dependent Manner but Does Not alter Spatial Learning and Reference MemoryDOI 10.21203/rs.3.rs-396650/v1Read

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