Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice.

Journal of neurochemistry - 1 Apr 2010

Kimura Ryoichi, Devi Latha, Ohno Masuo

Abstract excerpt

beta-Site amyloid precursor protein cleaving enzyme 1 (BACE1) initiates amyloid-beta (Abeta) generation that is central to the pathophysiology of Alzheimer's disease (AD). Therefore, lowering Abeta levels by BACE1 manipulations represents a key therapeutic strategy, but it remains unclear whether partial inhibition of BACE1, as expected for AD treatments, can improve memory deficits. In this study, we used...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid Precursor Protein Secretases
Share to Aspartic Acid Endopeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Conditioning, Classical

Share to Electric Stimulation

Share to Excitatory Postsynaptic Potentials

Share to Long-Term Potentiation

Share to Memory Disorders

Source

Open in PubMed Open full text

Identifiers

PMID: 20089133
DOI: 10.1111/j.1471-4159.2010.06608.x
PMCID: PMC2921968

Genes

BACE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice.PMID 20089133Read ↗

Involvement of β-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticitySemantic proximity Read ↗

BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic miceSemantic proximity Read ↗

Phospho-eIF2α Level Is Important for Determining Abilities of BACE1 Reduction to Rescue Cholinergic Neurodegeneration and Memory Defects in 5XFAD MiceSemantic proximity Read ↗

Genetic reductions of beta-site amyloid precursor protein-cleaving enzyme 1 and amyloid-beta ameliorate impairment of conditioned taste aversion memory in 5XFAD Alzheimer's disease model mice.Semantic proximity Read ↗

BACE1 partial deletion induces synaptic plasticity deficit in adult miceSemantic proximity Read ↗

Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model.Semantic proximity Read ↗

Presenilin 1 familial Alzheimer's disease mutation leads to defective associative learning and impaired adult neurogenesis.Semantic proximity Read ↗

Beneficial effects of the β-secretase inhibitor GRL-8234 in 5XFAD Alzheimer's transgenic mice lessen during disease progression.Semantic proximity Read ↗

Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP levelSemantic proximity Read ↗

Accelerated long-term forgetting is a BACE1 inhibitor-reversible incipient cognitive phenotype in Alzheimer's disease model mice.Semantic proximity Read ↗

Genetic modulation of soluble Aβ rescues cognitive and synaptic impairment in a mouse model of Alzheimer's disease.Semantic proximity Read ↗

BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.