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Article

BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization

23 Aug 2010

Abstract excerpt

BACKGROUND: BACE1 is a key enzyme in the generation of the Abeta peptide that plays a central role in the pathogenesis of Alzheimer's disease. While BACE1 is an attractive therapeutic target, its normal physiological function remains largely unknown. Examination of BACE1-/- mice can provide insight into this function and also help anticipate consequences of BACE1 inhibition. Here we report a...

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PMID: 20731874
DOI: 10.1186/1750-1326-5-31

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