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Article

BACE1 partial deletion induces synaptic plasticity deficit in adult mice

27 Dec 2019

Abstract excerpt

BACE1 is the first enzyme involved in APP processing, thus it is a strong therapeutic target candidate for Alzheimer's disease. The observation of deleterious phenotypes in BACE1 Knock-out (KO) mouse models (germline and conditional) raised some concerns on the safety and tolerability of BACE1 inhibition. Here, we have employed a tamoxifen inducible BACE1 conditional Knock-out (cKO) mouse model to achieve a...

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PMID: 31882662
DOI: 10.1038/s41598-019-56329-7

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