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Article

Centrally Delivered BACE1 Inhibitor Activates Microglia, and Reverses Amyloid Pathology and Cognitive Deficit in Aged Tg2576 Mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 29 Apr 2015

Thakker Deepak R, Sankaranarayanan Sethu, Weatherspoon Marcy R, Harrison Jonathan, Pierdomenico Maria, Heisel Jennifer M, Thompson Lorin A, Haskell Roy, Grace James E, Taylor Sarah J, Albright Charles F, Shafer Lisa L

Abstract excerpt

Multiple small-molecule inhibitors of the β-secretase enzyme (BACE1) are under preclinical or clinical investigation for Alzheimer's disease (AD). Prior work has illustrated robust lowering of central amyloid β (Aβ) after acute administration of BACE1 inhibitors. However, very few studies have assessed the overall impact of chronically administered BACE1 inhibitors on brain amyloid burden, neuropathology, and...

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Share to Amyloid beta-Peptides
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25926467
DOI: 10.1523/JNEUROSCI.2262-14.2015
PMCID: PMC6605183

Genes

BACE1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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