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Article

BACE1 deficiency causes altered neuronal activity and neurodegeneration.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 30 Jun 2010

Hu Xiangyou, Zhou Xiangdong, He Wanxia, Yang Jun, Xiong Wencheng, Wong Philip, Wilson Christopher G, Yan Riqiang

Abstract excerpt

BACE1 is required for the release of beta-amyloid (Abeta) in vivo, and inhibition of BACE1 activity is targeted for reducing Abeta generation in Alzheimer's patients. To further our understanding of the safe use of BACE1 inhibitors in human patients, we aimed to study the physiological functions of BACE1 by characterizing BACE1-null mice. Here, we report the finding of spontaneous behavioral seizures in...

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Identifiers

PMID: 20592204
DOI: 10.1523/JNEUROSCI.1334-10.2010
PMCID: PMC2902368

Genes

BACE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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