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Th17 cells require the DNA repair sensor XPC to control oxidative DNA damage

2024-09-19

Abstract excerpt

Th17 cells are critical for mucosal immunity, producing IL-17A, IL-17F, and IL-22, but dysregulated Th17 responses are implicated in autoimmune diseases. Despite their susceptibility to oxidative stress in certain conditions, Th17 cells exhibit reduced oxidative DNA damage and cell death compared to other T helper subsets. However, the mechanisms that protect Th17 cells from oxidative stress are poorly understood....

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Identifiers and source

Literature Corpus work
266fdc8c-1bf5-5dc4-b286-f32d23a05b37
DOI
10.1101/2024.09.13.612834
Open publication

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Th17 cells require the DNA repair sensor XPC to control oxidative DNA damageDOI 10.1101/2024.09.13.612834
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