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Article

AIM2 promotes TH17 cells differentiation by regulating RORγt transcription activity

4 Oct 2023

Abstract excerpt

AIM2 is an interferon-inducible HIN-200 protein family member and is well-documented for its roles in innate immune responses as a DNA sensor. Recent studies have highlighted AIM2's function on regulatory T cells (Treg) and follicular T cells (Tfh). However, its involvement in Th17 cell differentiation remains unclear. This study reveals that AIM2 promotes Th17 cell differentiation. AIM2 deficiency decreases...

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Identifiers

PMID: 37867943
DOI: 10.1016/j.isci.2023.108134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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