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Article

Xeroderma Pigmentosum Group C Deficiency Alters Cigarette Smoke DNA Damage Cell Fate and Accelerates Emphysema Development.

American journal of respiratory cell and molecular biology - 1 Mar 2018

Sears Catherine R, Zhou Huaxin, Justice Matthew J, Fisher Amanda J, Saliba Jacob, Lamb Isaac, Wicker Jessica, Schweitzer Kelly S, Petrache Irina

Abstract excerpt

Cigarette smoke (CS) exposure is a major risk factor for the development of emphysema, a common disease characterized by loss of cells comprising the lung parenchyma. The mechanisms of cell injury leading to emphysema are not completely understood but are thought to involve persistent cytotoxic or mutagenic DNA damage induced by CS. Using complementary cell culture and mouse models of CS exposure, we investigated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29111769
DOI: 10.1165/rcmb.2017-0251OC
PMCID: PMC5854959

Genes

XPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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