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Poly(ADP-Ribose) Mediates the BRCA2-Dependent Early DNA Damage Response

1 Oct 2015

Abstract excerpt

Breast cancer susceptibility gene 2 (BRCA2) plays a key role in DNA damage repair for maintaining genomic stability. Previous studies have shown that BRCA2 contains three tandem oligonucleotide/oligosaccharide binding folds (OB-folds) that are involved in DNA binding during DNA double-strand break repair. However, the molecular mechanism of BRCA2 in DNA damage repair remains elusive. Unexpectedly, we found that...

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PMID: 26489468
DOI: 10.1016/j.celrep.2015.09.040

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