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Article

Distinct roles of BRCA2 in replication fork protection in response to hydroxyurea and DNA interstrand cross-links.

Genes & development - 1 Jun 2020

Rickman Kimberly A, Noonan Raymond J, Lach Francis P, Sridhar Sunandini, Wang Anderson T, Abhyankar Avinash, Huang Athena, Kelly Michael, Auerbach Arleen D, Smogorzewska Agata

Abstract excerpt

DNA interstrand cross-links (ICLs) are a form of DNA damage that requires the interplay of a number of repair proteins including those of the Fanconi anemia (FA) and the homologous recombination (HR) pathways. Pathogenic variants in the essential gene BRCA2/FANCD1, when monoallelic, predispose to breast and ovarian cancer, and when biallelic, result in a severe subtype of Fanconi anemia. BRCA2 function in the FA...

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Share to BRCA2 Protein
Share to DNA Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Replication

Share to Fanconi Anemia

Share to Homologous Recombination

Share to Hydroxyurea

Share to Protein Domains

Share to Rad51 Recombinase

Source

Open in PubMed Open full text

Identifiers

PMID: 32354836
DOI: 10.1101/gad.336446.120
PMCID: PMC7263144

Genes

BRCA2
RAD51
DNA2
HLTF
MRE11
SMARCAL1
WRN
ZRANB3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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