Article

Pathogenic BRCA1 DBD variants exhibit altered DNA binding affinities and susceptibility to menadione

2025-07-14

Abstract excerpt

<h4>ABSTRACT</h4> Breast Cancer Susceptibility Gene 1 ( BRCA1 ) codes for a DNA repair protein that facilitates the repair of double-stranded DNA breaks (DSBs) in human cells through the homologous recombination (HR) pathway. Mutations of BRCA1 are highly associated with breast cancer; however, many variants remain unclassified with unknown cellular phenotypes. The DNA binding activity of BRCA1 is localized pri...

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Literature Corpus work: 141a1e6f-80b4-56ac-bdb9-d552d06ff968
DOI: 10.1101/2025.07.10.664210

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