Article

Measuring the Landscape of CpG Methylation of Individual Repetitive Elements

2015-04-24

Abstract excerpt

<h4>ABSTRACT</h4> Determining the methylation state of regions with high copy numbers is challenging for second-generation sequencing, because the read length is insufficient to map reads uniquely, especially when repetitive regions are long and nearly identical to each other. Single-molecule real-time (SMRT) sequencing is a promising method for observing such regions, because it is not vulnerable to GC bias, it...

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Literature Corpus work: 26630952-760b-56fa-b7ec-d4c8da5c8605
DOI: 10.1101/018531

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