Article

Transitory Schwann Cell Precursor and hybrid states underpin melanoma therapy resistance and metastasis

2022-10-17

Abstract excerpt

Melanoma plasticity, driven by phenotype state switching, underlies clinically relevant traits such as metastasis and therapy resistance. As melanoma progression is thought to recapitulate aspects of neural crest cell (NCC) development, understanding embryonic melanocyte specification and lineage fate decisions of closely related NCCs may illuminate the pathways co-opted during disease evolution. Here, we use a mo...

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Literature Corpus work: 262cee7d-9cea-5174-931a-3a030a01e980
DOI: 10.1101/2022.10.14.512297

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