Article
A parasitic fungus employs mutated eIF4A to survive on rocaglate-synthesizing Aglaia plants.
eLife - 28 Feb 2023
Chen Mingming, Kumakura Naoyoshi, Saito Hironori, Muller Ryan, Nishimoto Madoka, Mito Mari, Gan Pamela, Ingolia Nicholas T, Shirasu Ken, Ito Takuhiro, Shichino Yuichi, Iwasaki Shintaro
Abstract excerpt
Plants often generate secondary metabolites as defense mechanisms against parasites. Although some fungi may potentially overcome the barrier presented by antimicrobial compounds, only a limited number of examples and molecular mechanisms of resistance have been reported. Here, we found an Aglaia plant-parasitizing fungus that overcomes the toxicity of rocaglates, which are translation inhibitors synthesized by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.