Article

Deletion of astrocyte intermediate filaments GFAP and Vimentin enhances protein synthesis and prevents early synaptic and cognitive dysfunction in a mouse model of Alzheimer’s disease

2026-03-25

Abstract excerpt

In Alzheimer’s disease (AD) astrocytes become reactive, displaying hypertrophic morphology, increased expression of intermediate filament proteins GFAP and Vimentin and impaired homeostatic support to neurons. However, the contribution of reactive astrocytes to AD progression, particularly the role of cytoskeletal hypertrophy, remains unclear. Here, we investigate whether astrocyte intermediate filaments actively...

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Literature Corpus work: 3fe530dd-0297-5803-99b3-43a4d63d17a3
DOI: 10.64898/2026.03.24.713865

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