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Astrocytic Hevin/ SPARCL ‐1 Regulates Cognitive Decline in Pathological and Normal Brain Aging

12 Feb 2025

Abstract excerpt

Dementia, characterized by loss of cognitive abilities in the elderly, poses a significant global health challenge. This study explores the role of astrocytes, one of most representative glial cells in the brain, in mitigating cognitive decline. Specifically, we investigated the impact of Hevin (also known as SPARC-like1/SPARCL-1), a secreted glycoprotein, on cognitive decline in both normal and pathological...

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PMID: 39935382
DOI: 10.1111/acel.14493

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