Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder.

doi:10.1038/s41467-017-00831-x

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Article

Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder.

Nature communications - 17 Oct 2017

Noh Hyun Ji, Tang Ruqi, Flannick Jason, O'Dushlaine Colm, Swofford Ross, Howrigan Daniel, Genereux Diane P, Johnson Jeremy, van Grootheest Gerard, Grünblatt Edna, Andersson Erik, Djurfeldt Diana R, Patel Paresh D, Koltookian Michele, M Hultman Christina, Pato Michele T, Pato Carlos N, Rasmussen Steven A, Jenike Michael A, Hanna Gregory L, Stewart S Evelyn, Knowles James A, Ruhrmann Stephan, Grabe Hans-Jörgen, Wagner Michael, Rück Christian, Mathews Carol A, Walitza Susanne, Cath Daniëlle C, Feng Guoping, Karlsson Elinor K, Lindblad-Toh Kerstin

Abstract excerpt

Obsessive-compulsive disorder is a severe psychiatric disorder linked to abnormalities in glutamate signaling and the cortico-striatal circuit. We sequenced coding and regulatory elements for 608 genes potentially involved in obsessive-compulsive disorder in human, dog, and mouse. Using a new method that prioritizes likely functional variants, we compared 592 cases to 560 controls and found four strongly...

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Identifiers

PMID: 29042551
DOI: 10.1038/s41467-017-00831-x
PMCID: PMC5645406

Genes

NRXN1
CTTNBP2
REEP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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