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Article

Candidate genes and functional noncoding variants identified in a canine model of obsessive-compulsive disorder

14 Mar 2014

Abstract excerpt

BACKGROUND: Obsessive-compulsive disorder (OCD), a severe mental disease manifested in time-consuming repetition of behaviors, affects 1 to 3% of the human population. While highly heritable, complex genetics has hampered attempts to elucidate OCD etiology. Dogs suffer from naturally occurring compulsive disorders that closely model human OCD, manifested as an excessive repetition of normal canine behaviors that...

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PMID: 24995881
DOI: 10.1186/gb-2014-15-3-r25

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