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Article

Variation in crossover frequencies perturb crossover assurance without affecting meiotic chromosome segregation in Saccharomyces cerevisiae.

Genetics - 1 Feb 2015

Krishnaprasad Gurukripa N, Anand Mayakonda T, Lin Gen, Tekkedil Manu M, Steinmetz Lars M, Nishant Koodali T

Abstract excerpt

The segregation of homologous chromosomes during the Meiosis I division requires an obligate crossover per homolog pair (crossover assurance). In Saccharomyces cerevisiae and mammals, Msh4 and Msh5 proteins stabilize Holliday junctions and its progenitors to facilitate crossing over. S. cerevisiae msh4/5 hypomorphs that reduce crossover levels up to twofold at specific loci on chromosomes VII, VIII, and XV...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Crossing Over, Genetic

Share to High-Throughput Nucleotide Sequencing

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Source

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Identifiers

PMID: 25467183
DOI: 10.1534/genetics.114.172320
PMCID: PMC4317650

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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