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Article

Genetic analysis of mlh3 mutations reveals interactions between crossover promoting factors during meiosis in baker's yeast.

G3 (Bethesda, Md.) - 1 Jan 2013

Sonntag Brown Megan, Lim Elisha, Chen Cheng, Nishant K T, Alani Eric

Abstract excerpt

Crossing over between homologous chromosomes occurs during the prophase of meiosis I and is critical for chromosome segregation. In baker's yeast, two heterodimeric complexes, Msh4-Msh5 and Mlh1-Mlh3, act in meiosis to promote interference-dependent crossing over. Mlh1-Mlh3 also plays a role in DNA mismatch repair (MMR) by interacting with Msh2-Msh3 to repair insertion and deletion mutations. Mlh3 contains an...

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Identifiers

PMID: 23316435
DOI: 10.1534/g3.112.004622
PMCID: PMC3538346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic analysis of mlh3 mutations reveals interactions between crossover promoting factors during meiosis in baker's yeast.PMID 23316435Read ↗

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