Article

The SRG RAT® supports human cell xenotransplantation through enhanced tumor microenvironment interactions

2025-04-01

Abstract excerpt

The use of immunodeficient mice for human tumor engraftment is an essential model of human cancer, with uses ranging from basic science to translational research. However, low engraftment rates, slow growth, and smaller tumor volumes can be limitations. Previously, we reported a highly immunodeficient rat strain with the functional deletion of both the Rag2 and Il2rg genes on the Sprague-Dawley background ( SRG...

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Literature Corpus work: 25acf406-e59f-5ded-a958-683710849f1e
DOI: 10.1101/2025.03.27.645250

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